ULTRA LOW DOSE OF AEROSOLIZED MYCOBACTERIUM TUBERCULOSIS: MODEL OF PARTIAL INFECTION

摘要

The invention provides an animal model and methods for producing an animal model of partial Mycobacterium tuberculosis (MTB) infection. Methods for ultra-low dose administration of MTB or other bacterial pathogens for generating an experimental animal model of partial infection are disclosed. This animal model is useful for measuring vaccine efficacy and/or animal susceptibility or resistance following administration or exposure to vaccines, treatments or environmental agents.