首页> 外国专利> NANOPARTICLE-BASED VACCINE DELIVERY SYSTEM HAVING DOUBLE FUNCTIONS OF IMAGING AND DELIVERY

NANOPARTICLE-BASED VACCINE DELIVERY SYSTEM HAVING DOUBLE FUNCTIONS OF IMAGING AND DELIVERY

机译：具有成像和传送双重功能的基于纳米粒子的疫苗传送系统

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摘要

The present invention relates to a gold nanoparticle or a magnetic nanoparticle as a particle having a double function of imaging-delivering for imaging and delivery effects, an antigen-containing vaccine delivery system, an anticancer vaccine, and a pharmaceutical anticancer vaccine composition. The present invention rarely shows any in vivo toxicity and side effects, and can induce a high antigen generation rate even when used with an antigen having a low antigenicity. Also, the present invention effectively delivers and presents the antigen to an immunocyte, thus significantly inducing and enhancing an in vivo humoral (Th1) immune response and a cellular (Th2) immune response, and through such effects, enables immunoprophylaxis and immunotherapy against antigens causing various illnesses and diseases.

机译：金纳米粒子或磁性纳米粒子技术领域本发明涉及具有用于成像和递送效果的成像递送双重功能的金纳米粒子或磁性纳米粒子，含抗原的疫苗递送系统，抗癌疫苗和药物抗癌疫苗组合物。本发明很少表现出任何体内毒性和副作用，并且即使与低抗原性的抗原一起使用也可以诱导高的抗原产生速率。另外，本发明有效地将抗原递送并呈递给免疫细胞，从而显着诱导和增强体内的体液（Th1）免疫应答和细胞（Th2）免疫应答，并且通过这种作用，可以针对引起各种疾病的抗原进行免疫预防和免疫治疗。 展开▼

著录项

公开/公告号WO2012144716A1

专利类型

公开/公告日2012-10-26

原文格式PDF

申请/专利权人 GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY;JON SANGYONG;LEE IN-HYUN;
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申请/专利号WO2011KR09553

发明设计人 JON SANGYONG;LEE IN-HYUN;
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申请日2011-12-12

分类号A61K9/16;A61K49/08;A61K51;A61P35;

国家 WO

入库时间 2022-08-21 17:13:06

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3. Nanoparticle-based Vaccine Delivery System Having Dual Function of Imaging and Delivery [P] . 韩国专利： KR101376675B1 . 2014-03-20

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4. Nanoparticle-based vaccine delivery system containing adjuvant [P] . 美国专利： US2008124350A1 . 2008-05-29

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