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Pharmaceuticals compositions comprising sulphonylurea-class insulin secretagogue and polyethylene glycol castor oil

机译:包含磺酰脲类胰岛素促分泌剂和聚乙二醇蓖麻油的药物组合物

摘要

The present invention relates to the field of a pharmaceutical technology. More specifically, the present invention relates to a pharmaceutical composition comprising sulphonylurea-class insulin secretagogue and a surface active agent. Surface active agent obtainable by reacting castor oil or hydrogenated castor oil with ethylene oxide, preferably hydrogenated castor oil, substantially improves dissolution of the sulphonylurea-class insulin secretagogue active pharmaceutical ingredient and at the same time, when both formulated into a pharmaceutical composition, ensures satisfying or exceeding other parameters like for example stability, hardness, friability and handling of said pharmaceutical composition.
机译:本发明涉及制药技术领域。更具体地,本发明涉及包含磺酰脲类胰岛素促分泌剂和表面活性剂的药物组合物。通过使蓖麻油或氢化蓖麻油与环氧乙烷,优选氢化蓖麻油反应可获得的表面活性剂,显着改善了磺酰脲类胰岛素促分泌剂活性药物成分的溶解,同时,当两者均配制成药物组合物时,可确保令人满意的表面活性剂。或超过其他参数,例如所述药物组合物的稳定性,硬度,脆性和处理性。

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