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METHOD FOR PREDICTING A RISK OF CHRONIC MYELOID LEUKEMIA, AND DIAGNOSIS KIT USING SAME

机译：预测慢性粒细胞白血病的风险的方法以及使用相同方法诊断工具包

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摘要

The present invention relates to a method for predicting a risk of chronic myeloid leukemia, and a diagnosis kit using same. More particularly, the present invention relates to a composition for diagnosing chronic myeloid leukemia, comprising at least one gene selected from the group consisting of MTHFD1L, AKAP12, ZBTB2, RMND1, C6orf211, C6orf97, ESR1, WSB1, FAM27L, FLJ33360, and EBF1, and a single nucleotide polymorphism (SNP) positioned in a transcriptional regulation region or a sequence complementary thereto, and a diagnosis kit using the composition. The risk of developing chronic myeloid leukemia can be effectively predicted or diagnosed using a gene correlated with chronic myeloid leukemia and an SNP marker according to the present invention. Further, the present invention can be applied to the treatment of chronic myeloid leukemia and studies on the development of drugs.

机译：本发明涉及预测慢性粒细胞性白血病风险的方法和使用该方法的诊断试剂盒。更具体地，本发明涉及用于诊断慢性髓性白血病的组合物，其包含选自以下的至少一种基因：MTHFD1L，AKAP12，ZBTB2，RMND1，C6orf211，C6orf97，ESR1，WSB1，FAM27L，FLJ33360 / I>， EBF1 ，位于转录调控区或与其互补的序列中的单核苷酸多态性（SNP），以及使用该组合物的诊断试剂盒。使用与慢性粒细胞白血病相关的基因和根据本发明的SNP标记，可以有效地预测或诊断发生慢性粒细胞白血病的风险。此外，本发明可用于治疗慢性粒细胞白血病和药物开发的研究。 展开▼

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公开/公告号WO2012150818A2

专利类型

公开/公告日2012-11-08

原文格式PDF

申请/专利权人 SAMSUNG LIFE PUBLIC WELFARE FOUNDATION;KIM JONG WON;KIM DONG HWAN;LEE SEUNG TAE;WON HONG HEE;
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申请/专利号WO2012KR03445

发明设计人 KIM JONG WON;KIM DONG HWAN;LEE SEUNG TAE;WON HONG HEE;
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申请日2012-05-02

分类号C12Q1/68;C12N15/11;

国家 WO

入库时间 2022-08-21 17:12:52

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