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GENETICALLY MODIFIED RAT MODELS FOR PHARMACOKINETICS

机译：药代动力学的遗传修饰大鼠模型

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摘要

The present invention provides a desired rat or a rat cell which contains a predefined, specific and desired alteration rendering the rat or rat cell predisposed to drug transport sensitivity or resistance drug transport resistance or sensitivity. Specifically, the invention pertains to a genetically altered rat, or a rat cell in culture, that is defective in at least one of two alleles of a drug transporter gene such as the Slc7all (NC_005101.2) gene, the Abcbl (NC_005103.2) gene, etc. The present invention also provides a desired rat or a rat cell which contains a predefined, specific and desired alteration rendering the rat or rat cell predisposed to drug transport sensitivity or resistancedrug transport resistance or sensitivity. Specifically, the invention pertains to a genetically altered rat, or a rat cell in culture, that is defective in at least one of two alleles of a drug transporter gene.

机译：本发明提供了一种期望的大鼠或大鼠细胞，其包含预定义的，特异性的和期望的改变，使得该大鼠或大鼠细胞易受药物转运敏感性或耐药性的影响。具体地，本发明涉及遗传上改变的大鼠或培养中的大鼠细胞，其在诸如 Slc7all （NC_005101.2）基因的药物转运蛋白基因的两个等位基因的至少一个等位基因中有缺陷。， Abcbl （NC_005103.2）基因等。本发明还提供了所需的大鼠或大鼠细胞，其包含预定义的，特异性的和所需的改变，从而使该大鼠或大鼠细胞易于进行药物转运敏感性或耐药性具体地，本发明涉及在药物转运蛋白基因的两个等位基因中的至少一个等位基因中有缺陷的遗传改变的大鼠或培养中的大鼠细胞。 展开▼

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公开/公告号EP2460016A2

专利类型

公开/公告日2012-06-06

原文格式PDF

申请/专利权人 TRANSPOSAGEN BIOPHARMACEUTICALS INC.;
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申请/专利号EP20100752947

发明设计人 CRAWFORD JOHN STUART;OSTERTAG ERIC;
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申请日2010-07-30

分类号G01N33/68;

国家 EP

入库时间 2022-08-21 17:12:31

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focus on the nitric oxide pathwayAging395Heart failure with preserved ejection fraction develops when feeding western diet to senescence-accelerated mice396Cardiovascular markers as predictors of cognitive decline in elderly hypertensive patients397Changes in connexin43 in old rats with volume overload chronic heart failureGenetics and epigenetics400Calcium content in the aortic valve is associated with 1G>2G matrix metalloproteinase 1 polymorphism401Neuropeptide receptor gene s (NPSR1) polymorphism and sleep disturbances402Endothelin-1 gene Lys198Asn polymorphism in men with essential hypertension complicated and uncomplicated with chronic heart failure403Association of common polymorphisms of the lipoprotein lipase and pon1 genes with the metabolic syndrome in a sample of community participantsGenomics, proteomics, metabolomics, lipidomics and glycomics405Gene expression quantification using multiplexed color-coded probe pairs to determine RNA content in sporadic cardiac myxoma406Large-scale phosphorylation study of the type 2 diabetic heart subjected to ischemia / reperfusion injury407Transcriptome-based identification of new anti-inflammatory properties of the olive oil hydroxytyrosol in vascular endothelial cell under basal and proinflammatory conditions408Gene polymorphisms combinations and risk of myocardial infarctionComputer modelling, bioinformatics and big data411Comparison of the repolarization reserve in three state-of-the-art models of the human ventricular action potentialMetabolism, diabetes mellitus and obesity414Endothelial monocyte-activating polypeptide-II improves heart function in type -I Diabetes mellitus415Admission glucose level is independent predictor of impaired left ventricular function in patients with acute myocardial infarction: a two dimensional speckle-tracking echocardiography study416Association between biochemical markers of lipid profile and inflammatory reaction and stiffness of the vascular wall in hypertensive patients with abdominal obesity417Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening418Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity419Statins in the treatment of non-alcoholic steatohepatitis (NASH). 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