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TRIFLUOROMETHYLTHIOPHENIUM DERIVATIVE SALTS, PROCESS FOR PRODUCITON THEREOF, AND PROCESS FOR PRODUCTION OF TRIFLUOROMETHYL-CONTAINING COMPOUNDS USING SAME
TRIFLUOROMETHYLTHIOPHENIUM DERIVATIVE SALTS, PROCESS FOR PRODUCITON THEREOF, AND PROCESS FOR PRODUCTION OF TRIFLUOROMETHYL-CONTAINING COMPOUNDS USING SAME
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机译:三氟甲基噻吩衍生物盐,其制备方法以及使用相同的三氟甲基化合物的制备方法
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摘要
A trifluoromethylthiophenium derivative salt useful as synthetic intermediates for pharmaceuticals and agrochemicals, a method for producing the same, and a method for producing trifluoromethyl-containing compounds using the same are provided. An S-(trifluoromethyl)-benzo[b]thiophenium derivative salt is represented by the following general formula (1):wherein R1, R2, R3, and R4 are each independently a hydrogen atom, a methyl group, an ethyl group, a linear, branched, or cyclic alkyl group having 3 to 10 carbon atoms, a methoxy group, an ethoxy group, a linear, branched, or cyclic alkyloxy group having 3 to 10 carbon atoms, a fluorine atom, a chlorine atom, a bromine atom, a nitro group, or a cyano group, R5 is a methyl group, an ethyl group, a linear, branched, or cyclic alkyl group having 3 to 10 carbon atoms, a phenyl group, or a substituted phenyl group, and X- represents an anion. Various trifluoromethyl-containing compounds are produced using a method for producing the S-(trifluoromethyl)-benzo[b]thiophenium derivative salt, and using the S-(trifluoromethyl)-benzo[b]thiophenium derivative salt as a trifluoromethylating agent.
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机译:本发明提供了用作药物和农用化学品的合成中间体的三氟甲基噻吩衍生物盐,其制备方法和使用其制备含三氟甲基化合物的方法。 S-(三氟甲基)-苯并[b]噻吩衍生物的盐由以下通式(1)表示: <图像文件=“ IMGA0001.GIF” he =“ 56” id =“ ia01” imgContent =“ chem” imgFormat =“ GIF” wi =“ 100” /> Chemistry>其中R 1 Sup>,R 2 Sup>,R 3 Sup>和R 4 Sup>分别独立地为氢原子,甲基基团,乙基,具有3至10个碳原子的直链,支链或环状烷基,甲氧基,乙氧基,具有3至10个碳原子的直链,支链或环状烷氧基,氟原子, R 5 Sup>是氯原子,溴原子,硝基或氰基,是具有3至10个碳原子的甲基,乙基,直链,支链或环状烷基,苯基或取代的苯基,并且X - Sup>表示阴离子。使用制备S-(三氟甲基)-苯并[b]噻吩衍生物盐的方法,以及使用S-(三氟甲基)-苯并[b]噻吩衍生物盐作为三氟甲基化剂,可以制备各种含三氟甲基的化合物。
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