PHARMACEUTICAL COMPOSITION COMPRISING A PROTEASOME INHIBITOR AND A DOWN REGULATOR OF GALPHA12/GALPHA13 PROTEIN FUNCTION

摘要

PURPOSE: A composition containing a proteasome inhibitor and a down-regulator of G alpha12 and/or G alpha13 function is provided. CONSTITUTION: A pharmaceutical composition for suppressing tumor contains inhibitor of G alpha12 or G alpha 13, proteasome inhibitor, and pharmaceutically acceptable carrier. The function inhibitor and proteasome inhibitor are administered at once or separately. The inhibitor of G alpha12 function is a minigene encoding G alpha12 C-terminal, an antisense oligonucleotide to G alpha 12 gene, an antipeptide to G alpha12, a G alpha12 target siRNA, an antibody to G alpha12 receptor, or antagonist to the receptor.