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COMPOSITION AND METHODS FOR THE PREVENTION AND TREATMENT OF MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND DIABETIC MACULAR EDEMA
COMPOSITION AND METHODS FOR THE PREVENTION AND TREATMENT OF MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND DIABETIC MACULAR EDEMA
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机译:预防和治疗黄斑变性,糖尿病性视网膜病变和糖尿病性黄斑水肿的组合物和方法
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摘要
Methods of stabilizing and organizing collagen fibrils in extracellular matrix of retinal tissues, particularly Bruch's membranes, and stabilizing retinal pigment epithelial layers lining Bruch's membrane are disclosed. The stabilization and organization may be effected by treating retinal tissues with a protein that crosslinks and organizes collagen fibrils, such as decorin. The stabilization and organization methods include treatment of retinal tissues before, during, or after diagnosis of dry macular degeneration, diagnosis of early stages of diabetic retinopathy and diabetic macular edema to prevent, retard, or limit progression of disorganization of Bruch's membrane and disorganization of retinal pigment epithelial cells lining Bruch's membrane.
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