USE OF CYR61 PROTEIN FOR PREPARING MEDICINE

摘要

The present invention provides the use of CYR61 protein and inhibitors thereof for preparing medicine for treating rheumatic diseases, wherein the inhibitors are selected from anti-CYR61 antibody or interfering RNA of CYR61 gene. The technical scheme of present invention are: application of CUR61 protein in preparing medicine for treating rheumatic diseases; the rheumatic disease displayed here is rheumatoid arthritis (RA). The advantages of present invention are: discovering the usage of CYR61 as medicine; developing a new field for CYR61 application. Present invention displays the results that CYR61 has ability to enhance proliferation of fibroblast-like synoviocyte (FLS) derived from RA patients, which further results in damage of joint cartilage and bone in RA patients. CYR61 can inhibit FLS apoptosis while increases proliferation of FLS. Another way is that CYR61 induces expression of metal proteases up-regulation which further leads to damage of joint cartilage and bone. The invention also shows using some inhibitors, such as anti-CYR61 antibody or interfering RNA of CYR61 gene can block pathogenesis of CYR61. These results supply experimental evidences for screening therapeutic targets for biomedical and small molecules treatment in the future. The invention has the value for clinical application.