首页> 外国专利> PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF INFLAMMATORY DISEASES, ALLERGIC DISEASES OR ASTHMA COMPRISING EXTRACT OF DIOSPYROS BLANCOI A. DC. AS AN ACTIVE INGREDIENT

PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF INFLAMMATORY DISEASES, ALLERGIC DISEASES OR ASTHMA COMPRISING EXTRACT OF DIOSPYROS BLANCOI A. DC. AS AN ACTIVE INGREDIENT

机译：用于预防和治疗DIOSPYROS BLANCOI A. DC的炎症性疾病，过敏性疾病或哮喘的药物组合物。作为活性成分

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PURPOSE: A pharmaceutical composition containing Diospyros discolor extract for preventing and treating inflammatory and allergic diseases or asthma is provided to suppress iNOS and COX-2 expression. CONSTITUTION: A pharmaceutical composition for preventing and treating inflammatory or allergic diseases or asthma contains Diospyros discolor extract as an active ingredient. The extract is isolated using water, low alcohol of C1-C2, or a mixture thereof. An external use formulation for preventing and treating inflammatory or allergic diseases or asthma contains the Diospyros discolor extract as an active ingredient. A method for preparing or treating inflammatory or allergic diseases comprises a step of administering pharmaceutically active amount of the Diospyros discolor extract to an individual.

机译：目的：提供一种用于预防和治疗发炎性和过敏性疾病或哮喘的药物，该药物组合物含有薯os提取物以抑制iNOS和COX-2的表达。组成：用于预防和治疗炎症性或过敏性疾病或哮喘的药物组合物，其中含有柿叶黄连提取物作为有效成分。用水，C1-C2的低级醇或其混合物分离提取物。用于预防和治疗炎性或过敏性疾病或哮喘的外用制剂包含变色柿属提取物作为有效成分。一种制备或治疗炎性或过敏性疾病的方法，包括对个体施用药学上有效量的薯os提取物提取物的步骤。

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公开/公告号KR20120023500A

专利类型
公开/公告日2012-03-13

原文格式PDF
申请/专利权人 KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY;
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申请/专利号KR20110018950
发明设计人 AHN KYUNG SEOP;KWON OK KYOUNG;OH SEI RYANG;KIM JUNG HEE;LEE HYEONG KYU;PARK JI WON;JANG HA YOUNG;JOUNG HYOUK;LEE MEE YOUNG;SON HWA YOUNG;LEE KYOUNG YOUL;
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申请日2011-03-03
分类号A61K36/44;A61P29;A61P37/08;
国家 KR
入库时间 2022-08-21 17:10:26

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1. PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND ANTIDIABETIC EVALUATION OF LEAF EXTRACTS FROM DIOSPYROS BLANCOI A. DC. [J] . M. T. Demetillo, O. M. Nu?eza, M. M. Uy, International Journal of Pharmaceutical Sciences and Research . 2019,第8期

2. Probiotics for treatment and primary prevention of allergic diseases and asthma: looking back and moving forward [J] . West Christina E., Jenmalm Maria C., Kozyrskyj Anita L., Expert review of clinical immunology . 2016,第6期

3. Regulators of G protein signalling: potential targets for treatment of allergic inflammatory diseases such as asthma. [J] . Druey KM Expert opinion on therapeutic targets . 2003,第4期

4. Efficacy of the Specific Carbohydrate Diet for the Treatment of Patients with Active, Severe, Biologic-Refractory Inflammatory Bowel Disease [D] . Dabbah, Eliane. 2020

5. Active ingredients of ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities [O] . Arshad H Rahmani, Fahad M Al shabrmi, Salah M Aly 2014

6. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; focus on the nitric oxide pathwayAging395Heart failure with preserved ejection fraction develops when feeding western diet to senescence-accelerated mice396Cardiovascular markers as predictors of cognitive decline in elderly hypertensive patients397Changes in connexin43 in old rats with volume overload chronic heart failureGenetics and epigenetics400Calcium content in the aortic valve is associated with 1G>2G matrix metalloproteinase 1 polymorphism401Neuropeptide receptor gene s (NPSR1) polymorphism and sleep disturbances402Endothelin-1 gene Lys198Asn polymorphism in men with essential hypertension complicated and uncomplicated with chronic heart failure403Association of common polymorphisms of the lipoprotein lipase and pon1 genes with the metabolic syndrome in a sample of community participantsGenomics, proteomics, metabolomics, lipidomics and glycomics405Gene expression quantification using multiplexed color-coded probe pairs to determine RNA content in sporadic cardiac myxoma406Large-scale phosphorylation study of the type 2 diabetic heart subjected to ischemia / reperfusion injury407Transcriptome-based identification of new anti-inflammatory properties of the olive oil hydroxytyrosol in vascular endothelial cell under basal and proinflammatory conditions408Gene polymorphisms combinations and risk of myocardial infarctionComputer modelling, bioinformatics and big data411Comparison of the repolarization reserve in three state-of-the-art models of the human ventricular action potentialMetabolism, diabetes mellitus and obesity414Endothelial monocyte-activating polypeptide-II improves heart function in type -I Diabetes mellitus415Admission glucose level is independent predictor of impaired left ventricular function in patients with acute myocardial infarction: a two dimensional speckle-tracking echocardiography study416Association between biochemical markers of lipid profile and inflammatory reaction and stiffness of the vascular wall in hypertensive patients with abdominal obesity417Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening418Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity419Statins in the treatment of non-alcoholic steatohepatitis (NASH). 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V Garcia-Martinez, C Lopez Sanchez, W Hamed, 2016

1. Highly Active Antiretroviral Treatment (HAART) for the Prevention of HIV Mother to Child Transmission (PMTCT) at Roosevelt Hospital's Infectious Diseases Clinic in Guatemala: The Role of (LPV/r) Standard Dose [J] . Carlos Mejia Villatoro ,Maria Eugenia Luarte ,Guillermo Villatoro Natareno . 艾滋病（英文） . 2012,第3期

2. Treatment of active steroid-refractory inflammatory bowel diseases with granulocytapheresis: Our experience with a prospective study [J] . Bresci Giampaolo ,Parisi Giuseppe ,Bertoni Michele . 世界胃肠病学杂志：英文版 . 2006,第14期

3. Venous thromboembolism in patients with inflammatory bowel disease:Focus on prevention and treatment [J] . Alfredo Papa ,Viviana Gerardi ,Manuela Marzo . 世界胃肠病学杂志：英文版 . 2014,第12期

4. Active tuberculosis in inflammatory bowel disease patients under treatment from an endemic area in Latin America [J] . Flora Maria Lorenzo Fortes ,Ney Boa Sorte ,Victor D Mariano . 世界胃肠病学杂志：英文版 . 2020,第44期