COMPOSITION FOR DIFFERENTIATING INTO NATURAL KILLER CELLS, CONTAINING TOX(THYMOCYTE SELECTION-ASSOCIATED HMG BOX PROTEIN)

摘要

PURPOSE: A composition containing TOX and a method for differentiation method using the composition are provided to induce differentiation of hematopoietic stem cells into natural killer cells.;CONSTITUTION: A composition for differentiating into natural killer cells contains TOX(thymocyte selection-associated HMG box protein) as an active ingredient. A method for differentiating hematopoietic stem cell into natural killer cells comprises: a step of adding NK cell precursor derivatives to the hematopoietic stem cells to induce proliferation of NK cell precursor cells; and a step of administering TOX to the NK precursor cells. The NK cell precursor derivative is SCF, Fle3L or hydrocortisone.;COPYRIGHT KIPO 2012