PHARMACEUTICAL COMPOSITION CONTAINING JAWBONE NECROSIS INHIBITOR CONTAINING AMINE DERIVATIVES FOR PREVENTING OR TREATING JAWBONE NECROSIS

摘要

PURPOSE: A pharmaceutical composition containing a bisphosphonate agent with amine derivatives is provided to control HIF-1alpha expression, to suppress cell apoptosis, and to prevent and treat jawbone necrosis.;CONSTITUTION: A pharmaceutical composition for suppressing jawbone necrosis caused by side effects of bisphosphonate formulation contains amine derivatives as an active ingredient. The amine derivative prevents or treats jawbone by suppressing osteoblast apoptosis. The amine derivative is deferoxamine.;COPYRIGHT KIPO 2012