MSH3 EXPRESSION STATUS DETERMINES THE RESPONSIVENESS OF CANCER CELLS TO THE CHEMOTHERAPEUTIC TREATMENT WITH PARP INHIBITORS AND PLATINUM DRUGS

摘要

PURPOSE: A method for treating a patient with colorectal carcinoma or a risk of developing colorectal carcinoma is provided to predict therapeutic efficacy. CONSTITUTION: A method for predicting therapeutic efficacy from a patient with one or more adenocarcinoma or a risk of developing one or more adenocarcinoma comprises: a step of measuring total expression level of MSH3 in cells which are collected from a patient and are suspicious for adenocarcinoma; and a step of predicting therapeutic efficacy using an anti-neoplastic agent.