COMPOSITION FOR PREVENTING AND TREAING BRAIN DISORDER INCLUDING IMIPRAMINE AND FUSED PROTEIN WHICH IS COVALENTLY BONDED WITH PROTEIN TRANSPORT DOMAINS AND A METHOD FOR INCREASING THE INTRODUCTION OF THE FUSED PROTEIN

摘要

PURPOSE: A composition for preventing and treating brain disorder including imipramine and fused protein which is covalently bonded with protein transport domains and a method for increasing the introduction of the fused protein are provided to reduce cytotoxin induced by hydrogen peroxide.;CONSTITUTION: A method for increasing the introduction of the fused protein is processed by adding imipramine and fused protein which is covalently bonded with protein transport domains. The imipramine is primarily processed in the nerve cells or brain cells than the fusion protein. The protein transport domain is Tat, PEP-1, oligolysine, oligo arginine or oligo (the lysine, and the arginine). The therapeutic protein is active oxygen species excision enzyme. The therapeutic protein is catalase, superoxide dismutase or glutathione peroxidase. A composition for preventing and treating neural diseases or brain disorder includes the fused protein and imipramine of the enzyme having the removing activity of active oxygen species. The enzyme having the removing activity of active oxygen species is catalase, superoxide dismutase or glutathione peroxidase.;COPYRIGHT KIPO 2013