Nanofibrous silk nerve conduit for the regeneration of injured nerve and preparation method thereof

摘要

invention silk fiber from the spinning solution for producing silk fibers, and then it is prepared by electrospinning a diameter of about 200 to 400 the silk nanofibers intertwined with a gap formed silk nanofiber nerve conduit and a method relates to, specifically, to prepare a fiber spinning solution (step 1); The fiber spinning solution prepared in Step 1 of polyethylene oxide (polyethyleneoxide, PEO) by electrospinning in the coating step of manufacturing the collecting part by a duct-like silk nanofibers (step 2); And to a method for producing a silk nanofiber nerve conduit comprises a step (step 3) to separate the silk fiber of the prepared nano-like conduit portion as described in Step 2 from the collection. According to the present invention are silk nanofiber nerve conduit, as well as excellent biocompatibility, can be exchanged between the fluid conduit and out through the air gap, since proper elasticity and have a tensile strength and tear strength, to help the regeneration of damaged nerves Since the effect given to show the superior nerve regeneration to restore movement and sensory function in place of the conventional synthetic polymer nerve conduit can be very useful in treating nerve damage.