首页>
外国专利>
Methods for providing information for an inhibition prediction of hERG channel
Methods for providing information for an inhibition prediction of hERG channel
展开▼
机译:提供用于hERG通道抑制预测的信息的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
PURPOSE: A method for providing information of predicting hERG channel is provided to improve accuracy of hERG suppression and to remove unbalance of data. CONSTITUTION: A method for providing information of predicting hERG channel comprises: a step of colleting structure of compound having characteristic of suppressing hERG channel; a step of classifying active and inactive compounds based on activation value of suppressing hERG channel; and a step of selecting final descriptor by parameters optimization and genetic algorithm. The method is performed by ensemble model in a ratio of activation:inactivation=1:1.
展开▼