Process for preparing crystalline Form I Clopidogrel bisulfate

摘要

The present invention relates to a process for preparing clopidogrel hydrogensulfate Form I having a large particle size and containing 0.1% or less impurities, and clopidogrel hydrogensulfate Form I produced thereby. The process of the present invention allows a clopidogrel hydrogensulfate Form I to have a pharmaceutically useful particle size and an even spherical form, and to contain 0.1% or less of impurities.