Manufacturing method of methyl 5-aminolevulinate hydrochloride and cosmetic omposition for skin external application for improvement of pimpled skin, manufacturing method thereof

摘要

The present invention re-methyl-5-amino disadvantage carbonate hydrochloride Using this method and relates to a skin cosmetic composition for external use, and a method of manufacturing for acne and skin improvement, 5 that is effective for acne and skin improvement in detail amino a derivative of the parent phonograph introduced in order to increase the skin absorption of the 5-aminolevulinic aminolevulinic acid derivative salts of methyl 5-amino-manufacturing method of the LES disadvantage of carbonate and acid, methyl 5-amino-les base salts of the disadvantages Nate contain the formulation relates to a skin cosmetic composition for external use and a preparation method thereof that can be useful in wide use chemical therapy. ; Salt production method of methyl 5-amino-les disadvantage carbonate of the present invention is prepared by the addition of diethyl ether and then reacting the methanol, the acid value chloride hydrochloride 5-Amino-called LES then vacuum dried. ; Aminolevulinic acid, amino Les unfavorable carbonate, salt, hydrochloride, photodynamic acne, skin