Method for Separating of Optically Pure Thiophene Compounds Using Simulated Moving Bed Chromatography

摘要

The present invention is a continuous simulated moving bed (Simulated Moving Bed; SMB) using a simulated moving bed relates to a method for separating an optically active thiophene (Thiophene) compounds using adsorption separation processes, and more specifically from racemic thiophene compound of high purity has an optical activity by optical resolution thiophene-based, users can use a mixed solvent of a polar solvent to separate eluent when compound reduced by increasing the productivity considerably the capacity factor, the optical activity using a continuous simulated moving bed adsorptive separation process T It relates to a method of separating thiophene-based compounds. ; According to the method of the invention, the squeezing of the optically active D'glaucoma therapeutic agent for topical as well as to produce continuous the intermediate thiophene compounds of the imide (dorzolamide) in high purity from a racemic mixture, which can significantly increase the unit productivity per hour there is an advantage. ; Optical resolution, optically active, thiophene, continuous simulated moving bed, adsorption, Isola D'midfield