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GST- activated anticancer compound used in the treatment of other anti-cancer therapy for the sensitization and / or other improvement of the side effects of cancer treatment

机译:GST活化的抗癌化合物,用于治疗其他抗癌疗法,以提高和/或改善癌症治疗的副作用

摘要

Mammals, another anti-cancer therapy (ie a human being in particular, chemotherapy, molecular targeted therapy, biological therapy , and anti-cancer treatments, including the non-treatment with radiation therapy, GST- anti-cancer therapy as a treatment with a non-activated anticancer compound, or to each of the sensitized for use in combination and used, or two or more of them) as the sole therapy , or mammal, in particular the use of other active anti-cancer GST- compound in the manufacture of a medicament for improving the side effects of anticancer therapy in humans. Compositions containing GST- activated anticancer compound for the purpose. Sensitized by administration of a sufficient amount of the anticancer compound to the activated GST- mammal sensitive method for solidifying other anti-cancer therapies, especially humans. Improved by administration of a sufficient amount of active anti-cancer compound in GST- to mammal, in particular how to improve the side effect of cancer therapy in humans another. GST- activated anticancer compound is particularly preferably a compound arc U.S. Patent No. 5,556,942 as a hydrogen chloride salt, and more preferably square phosphamid.
机译:哺乳动物,另一种抗癌疗法(即特别是人类,化学疗法,分子靶向疗法,生物疗法和抗癌疗法,包括非放射疗法,GST-抗癌疗法作为抗癌疗法)。非活化的抗癌化合物,或将每种敏化剂组合使用,或将其中的两种或两种以上用作单一疗法,或哺乳动物,特别是其他活性抗癌GST-化合物在制造中的用途用于改善人类抗癌治疗副作用的药物的研究。为此目的,包含GST活化的抗癌化合物的组合物。通过向活化的GST-哺乳动物敏感方法投予足够量的抗癌化合物来敏化,以固化其他抗癌疗法,尤其是人类。通过向哺乳动物施用足够量的GST-中的活性抗癌化合物来改善,特别是如何改善人类癌症疗法的副作用。 GST活化的抗癌化合物特别优选为美国专利号5,556,942的化合物,其为氯化氢盐,更优选为方形磷酰胺。

著录项

  • 公开/公告号KR1011746850000B1

    专利类型

  • 公开/公告日2012-08-16

    原文格式PDF

  • 申请/专利权人

    申请/专利号KR1020067025870

  • 申请日2005-05-19

  • 分类号A61K31/337;A61K38/04;A61K31/282;A61K31/475;

  • 国家 KR

  • 入库时间 2022-08-21 17:07:36

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