Fusion protein or fusion peptide with increased half life by keeping long-acting activity, and method for increasing half life using the same

摘要

The present invention is used by the body to increase half-life of a protein or peptide fusions , and it maintains the body persistence relates to a method of increasing the half-life of the body . Fusion proteins or peptides according to the present invention , a physiologically active protein or bioactive peptides to alpha-1 -antitrypsin or at least one amino acid mutation which was coupled to the alpha-1 -antitrypsin variant serum half-life (T held by the body persistence _1/2 ) is the body stability is excellent, significantly higher than the specific bioactive proteins or bioactive peptides. Thus , protein or peptide fusions may be used in accordance with the present invention are useful for the development of a protein or peptide drug formulation persistence . ;