PHARMACEUTICAL COMPOSITIONS OF DUAL ACTION ON THE BASIS OF NADMOLECULAR STRUCTURES OF ANTAGONISTS / ANGIOTENZINE (ARB) RECEPTOR BLOCK AND NEUTRAL ENDEPEPTIDASE (NEP) INHIBITOR (NEP)

摘要

1. A solid oral dosage form comprising:! (a) a double acting compound in an amount of from about 4 to about 90% based on the weight of the composition and! (b) at least one pharmaceutically acceptable excipient. ! 2. A solid oral dosage form comprising:! (a) a double acting compound in an amount of 100, 200 or 400 mg in one unit dosage form and! (b) at least one pharmaceutically acceptable excipient. ! 3. The solid oral dosage form according to claim 1 or 3, wherein said double acting compound is a supramolecular complex. ! 4. The solid oral dosage form according to claim 3, wherein said supramolecular complex is the trisodium salt semi-pentahydrate [3 - ((1S, 3R) -1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate- (S ) -3'-methyl-2 '- (pentanoyl {2' '- (tetrazol-5-ylate) biphenyl-4'-ylmethyl} amino) butyric acid]. ! 5. The solid oral dosage form according to claim 4, wherein said solid oral dosage form is a tablet. ! 6. The solid oral dosage form according to claim 5, wherein said tablet is an immediate release formulation. ! 7. A method for preparing a solid oral dosage form comprising the steps of:! (A) mixing a double-acting compound with at least one pharmaceutically acceptable excipient to form a mixture! (b) directly compressing said mixture into a solid oral dosage form! and optionally compressing the final mixture into a solid oral dosage form. ! 8. A method of obtaining a solid oral dosage form comprising a herd