ANTIBODY AGAINST GLIPICAN-3 WITH IMPROVED KINETIC INDICATORS IN PLASMA

摘要

1. The antibody against glypican-3, which contains the variable region of the heavy chain of SEQ ID NO: 27 and the variable region of the light chain of SEQ ID NO: 29. ! 2. The antibody according to claim 1, containing a constant region of a human antibody. ! 3. The antibody according to claim 2, where the constant region contains the sequence of SEQ ID NO: 32 and 33.! 4. The antibody according to claim 1, where the antibody has a reduced amount of fucose attached to the Fc region of the antibody. ! 5. An anticancer composition comprising an effective amount of an antibody according to any one of claims 1 to 4 and a pharmaceutically acceptable carrier. ! 6. An anti-cancer agent containing an antibody according to claims 1 to 4 as an active ingredient. ! 7. The anti-cancer agent of claim 6, wherein the cancer is liver cancer. ! 8. A nucleic acid that encodes an antibody polypeptide according to any one of claims 1 to 4. ! 9. A host cell containing the nucleic acid of claim 8, for the production of antibodies according to any one of claims 1 to 4. ! 10. The host cell according to claim 9, where the host cell is an animal cell lacking a fucose transporter, an animal cell with fucosyl transferase removed, or an animal cell with a modified branched sugar chain. ! 11. A method for producing an antibody, comprising culturing a host cell according to claim 9 or 10 and isolating the polypeptide from the cell culture.