SCFV SYNTHETIC ANALOGUE OF VARIABLE SITES OF MONOCLONAL ANTIBODY 6313 / G2 TO ANGIOTENSIN II TYPE 1 RECEPTOR

摘要

1. A specifically binding molecule that! specifically binds to a peptide having the amino acid sequence EDGIKRIQDD, and! contains a polypeptide comprising the VL domain of an immunoglobulin associated with the VH domain of an immunoglobulin, wherein! the VL domain contains complementarity determining regions (CDRs) of VLCDR1, VLCDR2 and VLCDR3, and the! VH domain contains complementarity determining regions (CDRs) of VHCDR1, VHCDR2, VHCDR3, each of which accordingly has the following amino acid sequence, where! VHCDR1 is a GYSFTGYNMN! VHCDR2 is NIDPYYGGTTYNQKFKG! VHCDR3 is an EVDY! VLCDR1 is a RASKSVSTSGYSYMH! VLCDR2 is LVSNLES! VLCDR3 is a QHIRELTRSEG! or an amino acid sequence at least 70% identical to the indicated sequences. ! 2. The specific binding molecule of claim 1, wherein the amino acid sequences of the CDRs are as follows:! VHCDR1 is GYSFTGYNMN or GYSFTGYNMS,! VHCDR2 is NIDPYYGGTTYNQKFKG,! VHCDR3 is an EVDY,! VLCDR1 is a RASKSVSTSGYSYMH,! VLCDR2 is LVSNLES or LVSDLED,! VLCDR3 is a QHIRELTRSEG. ! 3. The specific binding molecule of claim 1, wherein the CDRs have the following amino acid sequences:! VHCDR1 is a GYSFTGYNMN,! VHCDR2 is NIDPYYGGTTYNQKFKG,! VHCDR3 is an EVDY,! VLCDR1 is a RASKSVSTSGYSYMH,! VLCDR2 is LVSNLES,! VLCDR3 is a QHIRELTRSEG,! or ! VHCDR1 is a GYSFTGYNMS,! VHCDR2 is NIDPYYGGTTYNQKFKG,! VHCDR3 is an EVDY,! VLCDR1 is a RASKSVSTSGYSYMH,! VLCDR2 is LVSNLES,! VLCDR3 is a QHIRELTRSEG,! or ! VHCDR1 �