Gelling MIXED-phosphorus acid and dextran carbamate ESTERS, PROCESS FOR THEIR PREPARATION

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to medicine and represents gel-forming mixed dextran esters containing phosphate and carbamate groups of general formula: {C₆H₇O₂(OH)_3-x-y{[(OP(O)ONa)_mONa)]_xl[(O₂P(O)ONa)_k]x₂}_x(OCONH₂)_y}_n, wherein x=x₁+x₂ is a degree of substitution in phosphate groups (mono- and diesters), x=0.47-1.09; X₁ is a degree of substitution in monoesters, X₁=0.01-0.48; m is a number of phosphates in monoesters, m=1-2; x₂ is a degree of substitution in diesters, x₂=0.01-1.09; k is a number of phosphates in diesters, k=1-2; y is a degree of substitution in carbamate groups, y=0.39-1.23; n is a degree of polymerisation, 20≥n≤1000.;EFFECT: invention provides producing low-toxic low- and high-substituted dextran phosphates in the form of hydrogels containing additionally carbamate groups and possessing antiproliferative activity with respect to cancer cells.;2 cl, 3 dwg, 14 ex