THERAPEUTIC DERIVATIVES OF N-Aryl- OR N-HETEROARYLPYRAZOLIDINE AND PYRAZOLIDINO

摘要

1. A compound having a structure! ! or a pharmaceutically acceptable salt or prodrug thereof, wherein a dotted line indicates the presence or absence of a bond,! Y represents or,! A is - (CH2) 6-, cis-CH2-CH = CH- (CH2) 3- or -CH2-C≡C- (CH2) 3-, where 1 or 2 carbon atoms can be replaced by S or O, or A is - (CH2) m-Ar- (CH2) o-, where Ar is interalen or hetero-interralen, the sum of m and o is 1, 2, 3 or 4, and where one CH2 group can be replaced by S or O ! U1 and U2 independently represent hydrogen, O or S,! J1 represents H, O, OH, O-alkyl containing 1, 2, 3, 4, 5, or 6 carbon atoms, alkyl containing 1, 2, 3, 4, 5, or 6 carbon atoms, F, Cl, Br , I, CN or CF3,! B is a substituted aryl or substituted heteroaryl. ! 2. The compound according to claim 1, having the structure! ! or a pharmaceutically acceptable salt or prodrug thereof! where R represents hydrogen or a hydrocarbon radical C1-10. ! 3. The compound according to claim 1, having the structure! ! or a pharmaceutically acceptable salt or prodrug thereof! where R represents hydrogen or a hydrocarbon radical C1-10. ! 4. The compound according to claim 1, having the structure! ! or a pharmaceutically acceptable salt or prodrug thereof! where R represents hydrogen or a hydrocarbon radical C1-10. ! 5. The compound according to claim 1, having the structure! ! or a pharmaceutically acceptable salt or prodrug thereof! where R represents hydrogen or a hydrocarbon radical C1-10. ! 6. The compound according to claim 1, having the structure! ! or a pharmaceutically acceptable salt or prodrug thereof! where R represents hydrogen or a hydrocarbon radical C1-10. ! 7. A method of treating baldness, including the introduction of n�