METHOD FOR PREDICTING THE STABILITY erythrocyte membranes newborns from mothers who had experienced in the third trimester acute herpes virus infection

• 1. 一种妊娠期糖尿病的妊娠中期诊断标志物及其检测方法 [P] . 中国专利： CN108732356A . 2018-11-02
• 2. 心脏病妊娠患者分娩前新生儿风险预测方法、系统及介质 [P] . 中国专利： CN109754884B . 2020.05.08
• 3. METHOD FOR PREDICTING THE STABILITY erythrocyte membranes newborns from mothers who had experienced in the third trimester acute herpes virus infection [P] . 俄罗斯专利： RU2010154619A . 2012-07-10

  机译： 预测在妊娠中期急性疱疹病毒感染中来自母亲的新生儿的红细胞膜的方法

• 4. METHOD OF ASSESSING INFLUENCE OF HERPES VIRUS INFECTION ON ERYTHROCYTE MEMBRANE STABILITY IN NEWBORNS OF MOTHERS SUFFERED AGGRAVATED HERPES VIRUS INFECTION IN THIRD TRIMESTER OF PREGNANCY [P] . 俄罗斯专利： RU2488112C1 . 2013-07-20

  机译： 评估妊娠第三季接受疱疹病毒感染的母亲新生儿疱疹病毒感染对红细胞膜稳定性影响的方法。

• 5. METHOD OF ASSESSING INFLUENCE OF HERPES VIRUS INFECTION ON ERYTHROCYTE MEMBRANE STABILITY IN NEWBORNS OF MOTHERS SUFFERED AGGRAVATED HERPES VIRUS INFECTION IN THIRD TRIMESTER OF PREGNANCY [P] . 俄罗斯专利： RU2485505C1 . 2013-06-20

  机译： 评估妊娠第三季接受疱疹病毒感染的母亲新生儿疱疹病毒感染对红细胞膜稳定性影响的方法。

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• 1. The Fusability of Erythrocytes as a Method for Evaluating the Instability of Their Membranes [J] . Yury A. Sheremet’ev ,Aleksandra N. Popovicheva ,Methun M. Rogozin . 生物物理学期刊（英文） . 2013,第3期
• 2. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 3. Respiratory syncytial virus and adenovirus in acute lower respiratory infections in hospitalized infants and children [J] . Salvatore Barberi ,Mario Barreto ,Francesco La Penna . 儿科学期刊（英文） . 2012,第1期
• 4. 新生儿单纯疱疹病毒感染 [C] . 杨玉萍 . 山东省儿科2016年学术大会 . 2016
• 5. 应用GC--MS方法研究代谢标志物在预测造血干细胞移植后aGVHD和疱疹病毒感染中的作用 [A] . 谢伊瑜 . 2019