Thiazolo 5,4-B pyridine derivatives and oxazalo 5,4-B pyridine derivatives as antimicrobial agents

摘要

1. The compound of formula (I):! ! where Y means S or O! Q means C (= O) NR4, C (= S) NR5, C (= O) O, C (= NH) NR6, C (= NCN) NR7, SO2NR8, C (= O) C (= O) NR9 , or C = O, SO2; ! R4, R5, R6, R7, R8, R9 are independently selected from H, OH, C1-4 alkyl, and C3-6 cycloalkyl; ! R1 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C3-7 cycloalkyl, aryl, aryl C1-6 alkyl or heterocyclyl; ! X is N or CRa, where Ra is H, F, CH3, OCH3, CN; ! m = 0-5,! ring A means a carbocyclic or heterocyclic ring system containing up to 12 ring atoms and up to 5 heteroatoms, each of which is independently selected from N, O and S; where if said heterocyclyl contains an —NH moiety, then nitrogen may optionally be substituted with an R10 group; ! R3 is hydrogen, halo, nitro, cyano, hydroxy, amino, carboxy, carbamoyl, mercapto, sulfamoyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 alkanoyl, C1-6 alkanoyloxy, N- (C1 -6alkyl) amino, N, N- (C1-6alkyl) 2amino, C1-6alkanoylamino, N- (C1-6alkyl) carbamoyl, N, N- (C1-6alkyl) 2carbamoyl, N- (C1-6alkoxy) carbamoyl, N , N- (C1-6alkoxy) 2carbamoyl, C1-6alkylS (O) a, where a is 0-2, C1-6alkoxycarbonyl, C1-6alkoxycarbonylamino, N- (C1-6alkyl) sulfamoyl, N, N- (C1- 6alkyl) 2sulfamoyl, C1-6alkylsulfonylamino, carbocyclyl-R11- or heterocyclyl-R12-; where R3 may optionally be carbon substituted with one or more R13-; and where if said heterocyclyl contains an —NH moiety, then nitrogen may optionally be substituted with a group selected from R14; ! carbon substituents are independently selected from halo, nitro, cyano, hydroxy, amino, carboxy, carbamoyl, mercapto, sulfamoyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 alkanoyl, C1-6 alkanoyloxy, N- (C1-6alkyl) amino, N, N- (C1-6alkyl) 2amino, C1-6alkanoylamino, N- (C1-6alkyl) carbamoyl, N,