KIZELSOL-MATERIAL, AT LEAST, WITH ONE THERAPEUTICALLY ACTIVE SUBSTANCE FOR OBTAINING BIOLOGICALLY DEGRADABLE AND / OR INHIBITED KISELGEL MATERIALS FOR HUMAN AND HUMAN MEDICINES

摘要

1. Kieselzol is a material with at least one therapeutically active substance, obtained in such a way that! a) carry out the hydrolysis-condensation reaction of one or more Si compounds of the formula (I)! ! wherein the X moieties are the same or different and are hydroxy, hydrogen, halogen, amino, alkoxy, acyloxy, alkylcarbonyl and / or alkoxycarbonyl and are derived from alkyl residues, which are optionally substituted, linear, branched or cyclic residues with 1 -20 carbon atoms, preferably with 1-10 carbon atoms, and can be interrupted by oxygen or sulfur atoms or amino groups! catalyzed by acids at an initial pH of 0 to ≤7, if necessary, in the presence of a water-soluble solvent, for at least 16 hours, at a temperature of 0 ° C to 80 ° C,! b) a post-evaporation results in the formation of a single-phase solution with a viscosity in the range from 0.5 to 2 Pa · s at a shear rate of 10 s-1 at 4 ° C,! c) this solution is then cooled and! d) is subjected to kinetically controlled ripening, in which case a homogeneous single-phase sol is formed, and at least one therapeutically active is added to it at one or more stages a) to d) and preferably at one or more stages a) to c) substance. ! 2. Kieselzol material according to claim 1, characterized in that nitric acid water is used in acidic catalysis in a molar ratio in the range from 1: 1.7 to 1: 1.9, preferably in the range from 1: 1.7 to 1: 1.8, and the hydrolysis-condensation reaction is carried out for at least 16 hours, preferably 18 hours, and at a temperature between 20 and 60 ° C, particularly preferably at room temperature (from 2