Pyridine derivatives as vascular endothelial growth factor receptor inhibitor receptor 2 subtype (VEGFR-2) and protein kinase

摘要

1. The compound of the General formula! ! where R1 represents hydrogen or a direct saturated or unsaturated C1-2 hydrocarbon radical; ! R2 and R3 are hydrogen or a straight or branched saturated or unsaturated C1-6 hydrocarbon radical; ! D represents nitrogen or CH; ! E represents nitrogen or CH; ! G represents nitrogen or CH; ! J represents nitrogen or CH; ! L represents nitrogen or CH; ! n is an integer of 1 or 2; ! W represents oxygen or sulfur; ! R4 is hydrogen, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C1-6 hydroxyalkyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C2-7 heterocycloalkyl, C6-12 aryl, C3-12 heteroaryl or C2-7 heterocycloalkenyl, where indicated C1-10 alkyl , C2-10 alkenyl, C2-10 alkynyl, C1-6 hydroxyalkyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C2-7 heterocycloalkyl, C6-12 aryl, C3-12 heteroaryl or C2-7 heterocycloalkenyl are optionally substituted with one or more identical or different substituents independently selected from the group consisting of hydrogen, halogen, oxo, hydroxy, trifluoromethyl, carboxy, cyano, C1-6alk la, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkoxycarbonyl, C1-6 alkylthio, trifluoromethyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C2-7 heterocycloalkyl, C2-7 heterocycloalkenyl, C6-12 aryl, C3-12 heteroaryl and C1-6alkyl, C2-6alkenyl, C1-6alkoxy, C1-6alkoxycarbonyl, C1-6alkylthio, trifluoromethyl, C3-6cycloalkyl, C3-8cycloalkenyl, C2-7 heterocycloalkyl, C2-7 heterocycloalkenyl, C6-12 aryl, C3-12 heteroarylo and substituted by one or more identical or different substituents independently selected from hydroxy, C1-4 alkyl, C1-4 alkyloxycarbonyl but; ! or R3 and R4 together form part of a C3-8 cycloalkyl