ETHYL-2-AMINO-7,7-DIMETHYL-2',5-DIOXO-5'-PHENYL-1',2',5,6,7,8-HEXAHYDROSPIROCHROMEN-4,3'-PYRROL-4'-CARBOXYLATES AND METHOD FOR PRODUCING THEM

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to new compounds of the class spiro[chromen-4,3'-pyrrols], namely to ethyl 1'-R¹-3-R²-2-amino-7,7-dimethyl-2', 5-dioxo-5'-phenyl-1',2',5',6,7,8-hexahydrospiro [chromen-4,3'-pyrrol]-4'-carboxylates of formula , where R¹=CH₂Ph, Ph, C₆H₁₁-c, H; R²=CN, COOMe, and to a method for producing them by reaction of 1'-R¹-4,5-dioxo-2-phenyl-4,5-dihydro-1H-pyrrol-3-carboxylates with malononitrile or methyl cyanoacetate and dimedone in a aprotonic solvent medium.;EFFECT: production of new compounds which can be used as initial products for synthesis of new heterocyclic systems and in pharmacology as those exhibiting analgesic activity.;5 cl, 1 tbl