METHOD OF INTRODUCTION OF PNA MOLECULE CONJUGATED WITH POSITIVE PEPTIDE, IN CYTOSOL AND/OR NUCLEUS BY PHOTOCHEMICAL INTERNALISATION (PCI)

摘要

FIELD: medicine.;SUBSTANCE: method provides contact of said cell with a peptide nucleic acid (PNA) molecule and a photosensitising agent and cell exposure to light at wave length effective to activate the photosensitising agent where said PNA molecule is conjugated with positive peptide. Also, there are described compositions containing such conjugated PNA molecules, the cells produced with the use of the method, and application of the method.;EFFECT: effective cell capture of peptide nucleic acid molecules conjugated with positive peptide.;37 cl, 13 dwg, 9 ex