FIELD: medicine.;SUBSTANCE: recombinant vector of Newcastle disease virus contains an additional transcription unit including a gene coding HA protein of pathogenic avian influenza virus H5 operatively related with a gene start sequence of an initial portion of Newcastle disease virus and a gene end sequence of an end portion of Newcastle disease virus, characterised by the fact that said protein contains an elongation portion consisting of at least three essential amino acids where said elongation portion consists of arginine (Arg) and/or lysine (Lys) residues and contains at least one lysine with said gene not containing a sequence which can be recognised by a viral polymerase of Newcastle disease virus as an end gene sequence.;EFFECT: presented vector enables high expression level of HA protein of pathogenic avian influenza virus H5, as well as vaccine containing such vector provides an immune protection against Newcastle disease virus and avian influenza virus infection.;12 cl, 5 dwg, 1 tbl, 8 ex
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机译：领域：医学;实体：新城疫病毒的重组载体包含一个额外的转录单元，该转录单元包括与新城疫病毒的初始部分的基因起始序列和基因末端序列可操作地相关的编码致病性禽流感病毒H5 HA蛋白的基因新城疫病毒末端部分的特征在于所述蛋白质包含由至少三个必需氨基酸组成的延伸部分，其中所述延伸部分由精氨酸（Arg）和/或赖氨酸（Lys）残基组成并且至少包含一种赖氨酸，其中所述基因不包含可以被新城疫病毒的病毒聚合酶识别的序列作为末端基因序列。含有这种载体的疫苗提供了针对新城疫病毒和禽流感病毒感染的免疫保护。; 12 cl，5 d wg，1汤匙，8前
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