KAPPA-OPIOID AGONISTS FOR TREATMENT OF DIARRHEA-PREVAILING IRRITABLE BOWEL SYNDROME AND ALTERNATE IRRITABLE BOWEL SYNDROME

摘要

FIELD: medicine.; SUBSTANCE: group of inventions is referred to medicine and is meant for treatment of diarrhea or diarrhea-prevailing irritable bowel syndrome (IBS-D) or IBS with alternate diarrhea and constipation (IBS-A). Peripherally selective kappa-opioid agonist is used, particularly N-methyl-N-[(1S)-1-phenyl-2-((3S))-3-hydroxypyrrolidine-1-yl) ethyl]-2,2- diphenylacetamide and/or its pharmaceutically acceptable salt. The dose is 0.3 mg - 2.0 mg/day.; EFFECT: reduction of IBS symptoms and stool frequency with diarrhea.;28 cl, 5 tbl, 2 ex, 14 dwg