, where R=H (Ia), CH3 (Ib). The method is realised by reacting hydrogen sulphide-saturated aldehyde (formal or acetic) with a mixture of isonicotinic acid hydrazide - BuONa (1:3, pH11.5). The process is carried out at ratio hydrazide: aldehyde: H2S equal to 1:3:2, at temperature 40°C while stirring constantly for 4 hours, followed by neutralisation with a calculated quantity of dilute HCl and purification via column chromatography on SiO2. The substances obtained using the disclosed method can be used as radiation protection, antitumour and diuretic agents, as well as selective sorbents and extractants of noble and precious metals.;EFFECT: obtaining amide-containing 1,3,5-dithiazinanes of general formula (I).;2 ex"/>
公开/公告号RU2447072C2
专利类型
公开/公告日2012-04-10
原文格式PDF
申请/专利号RU20100100549
发明设计人 DZHEMILEV USEIN MEMETOVICH;AKHMETOVA VNIRA RAKHIMOVNA;KHAJRULLINA REGINA RADIEVNA;KUNAKOVA RAJKHANA VALIULLOVNA;
申请日2010-01-11
分类号C07D417/12;C07D213/82;
国家 RU
入库时间 2022-08-21 17:06:08