LOW MOLECULAR WEIGHT HEPARIN COMPOSITIONS AND APPLICATION THEREOF

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: group of invention relates to low molecular weight heparin (LMWH) compositions. Characteristic of the heparin compositions are weight-average molecular weight from 5500 to 8500 Da, anti-IIa activity from 170 to 330 IU/mg, anti-Pa activity from 130 to 190 IU/mg, the anti-IIa/anti-Pa activities ratio being from 2:1 to 1:1 during 30 - 120 minutes after administration to the patient. The heparins composition has improved properties, in particular - those ensuring clinical advantage, such as: action reversibility in response to protamine sulfate, improved anti-Pa activity, relatively stable ratio of anti-IIa/anti-Pa activities in the course of a certain interval of time, a traceable level of activity, bioavailability in case of subcutaneous administration, reduced probability of heparin-induced thrombocytopenia (HIT) development.;EFFECT: thrombotic diseases are prevented and treated using these compositions.;28 cl, 17 dwg, 20 tbl, 13 ex