METHOD FOR PREVENTION OF ACUTE GRAFT-VERSUS-HOST DISEASE FOLLOWING MARROW ALLOGRAFTING

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, more specifically to haematology, and is applicable for immune response modulation, particularly for prevention of acute graft-versus-host disease following marrow allografting. Donor multipotent mesenchymal stromal cells recovered from bone marrow, cultured on a human blood plasma medium enriched in platelet lysate are introduced intravenously in the amount of 1x10⁶ grafted cells per one kg of patient's body weight at the moment of leukocyte recovery in patient's peripheral blood following marrow allografting min. 1.0×10⁹/l.;EFFECT: method provides effective prevention of acute graft-versus-host disease following marrow allografting.;5 ex