METHOD OF PRODUCING L-CYSTEINE, L-CYSTINE, S-SULPHOCYSTEINE OR L-CYSTEINE THIAZOLIDINE DERIVATIVE, OR MIXTURE THEREOF USING BACTERIA OF ENTEROBACTERIACEAE FAMILY

摘要

FIELD: chemistry.;SUBSTANCE: disclosed is bacteria of the Enterobacteriaceae family - a producer of L-cysteine, which is modified such that expression of the following is intensified therein: one or more genes of the cysDNC cluster participating in sulphate activation; or one or more genes of the cysDNC cluster participating in activation of sulphate and a cysQ gene participating in decomposition of adenosine-3'-phosphate-5'-phosphosulphate (PAPS). Disclosed are methods of producing L-cysteine, L-cystine, S-sulphocysteine and L-cysteine thiazolidine derivative, involving: growing said bacteria in a culture medium which contains sulphate; and respectively separating L-cysteine, L-cystine, S-sulphocysteine or L-cysteine thiazolidine derivative from the culture fluid.;EFFECT: invention increases output of said products.;20 cl, 2 tbl, 5 dwg, 6 ex