SILVER NANOCOMPOSITE OF SULPHATED ARABINOGALACTAN EXHIBITING ANTIMICROBIAL AND ANTITHROMBOTIC ACTIVITY AND METHOD FOR PREPARING IT

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: group of inventions refers to medicine. A method for preparing a silver nanocomposite of semi-synthetic heparinoid - sulphated arabinogalactan (AGSO₃H) in the form of the silver-containing system (AGSO₃H +Ag°) of zero-valent metallic silver nanoclusters of particle size 10-15 nm (X-ray diffraction analysis) stabilised by sulphated arabinogalactan (AGSO₃H) by the reaction of sulphated arabinogalactan in an aqueous medium for 30-60 minutes at temperature 20°C and silver oxide (Ag₂O) accompanied by the product recovery. The silver content evaluated by atomic absorption analysis makes 8%.;EFFECT: group of inventions provides maintaining the structural organisation of silver nanocomposite and sulphated arabinogalactan (nanostructuredness of the biopolymer macromolecule system - particle oversize sinter size makes 200-600 nm), as well as water-solubility, biocompatibility, receptor-mediated transmembrane and immunomodulatory properties in relation or a living cell, antithrombotic activity, prolonged biological action, non-toxicity, synergism of antibacterial activity of silver.;2 cl, 3 dwg, 3 ex