USE OF ANTI-CD20 ANTIBODY FOR THE TREATMENT OF PRIMITIVE CEREBRAL LYMPHOMA

摘要

The present invention relates to a monoclonal antibody directed against the CD20 antigen, whose variable region of each of the light chains is encoded by the murine nucleic acid sequence SEQ ID NO: 1, the variable region of each of the heavy chains is encoded by the murine nucleic acid sequence SEQ ID NO: 2, and whose constant regions of the light and heavy chains are from a non-murine species, for use in the treatment of primary brain lymphoma. The present invention also relates to an antibody directed against an antigen present on the surface of primitive ceral lymphoma cells for its use by intrathecal administration in the treatment of primary brain lymphoma.