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Human follicle-stimulating hormone sustained-release preparation using immunoglobulin fragment
Human follicle-stimulating hormone sustained-release preparation using immunoglobulin fragment
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机译:使用免疫球蛋白片段的人促卵泡激素缓释制剂
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摘要
The present invention relates to a long-acting human follicle-stimulating hormone formulating having improved in vivo duration and stability, comprising a human follicle-stimulating hormone conjugate that is prepared by covalently linking human follicle-stimulating hormone with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting human follicle-stimulating hormone formulation of the present invention maintains in vivo activity of human follicle-stimulating hormone at a relatively high level and remarkably increases the serum half-life thereof.
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