REMOVAL OF SILICA FROM WATER SOLUBLE COMPOUND BY NANOFILTRATION AND REVERSE PHASE CHROMATOGRAPHY

摘要

PROBLEM TO BE SOLVED: To remove silica from a water soluble compound by nanofiltration and reverse phase chromatography.SOLUTION: A process for separating soluble silica species (for example, monomeric silicic acid (or monosilicic acid)) and low molecular weight soluble polymeric silica from impure water soluble compounds by membrane nanofiltration is provided. A process for separating soluble silica species and colloidal silica from impure water soluble compounds by reverse phase liquid chromatography is also provided. One aspect of the invention is directed to a process for refining a product solution containing a product compound, and silica species selected from at least one kind of soluble monosilicic acid, soluble polymer silica and colloidal silica.