USE OF GPR119 RECEPTOR AGONIST FOR INCREASING BONE MASS AND TREATING OSTEOPOROSIS, AND COMBINATION THERAPY RELATED TO THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a means for achieving an increase in an active level of endogenous GIP either independently of use of a DPP-IV inhibitor or by using a considerably lower level of the DPP-IV inhibitor than intended nowadays.SOLUTION: Provided is the use of the GPR119 receptor agonist for treatment or prevention of a state characterized by low bone mass such as osteoporosis, and for increasing bone mass in an individual. Also, provided is the use GPR119 receptor agonist combined with a dipeptidyl peptidase IV (DPP-IV) inhibitor for treatment or prevention of the state characterized by low bone mass such as osteoporosis, and for increasing bone mass in the individual. The GPR 119 receptor agonist and its combination with the DPP-IV inhibitor promote bone forming in an individual.