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Factor 7 (Factor VIIa) drug conjugate using immunoglobulin fragments
Factor 7 (Factor VIIa) drug conjugate using immunoglobulin fragments
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机译:使用免疫球蛋白片段的因子7(因子VIIa)药物偶联物
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摘要
Disclosed are a blood coagulation factor complex in which FacVIIa, a non-peptidyl polymer and an immunoglobulin Fc region are bonded by covalent bonds, and the uses thereof. The FacVIIa complex guarantees the in vivo activity of FacVIIa and significantly enhances the serum half life of FacVIIa, so that it is useful for developing long-acting FacVIIa formulations which can improve the compliance of role behavior of patients whose blood does not coagulate.
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