THERAPEUTIC AGENT FOR LIVER CANCER, HEPATOBLASTOMA, AND PANCREAS CANCER

摘要

PROBLEM TO BE SOLVED: To provide a therapeutic agent that is effective in liver cancer, hepatoblastoma, and pancreas cancer.SOLUTION: The therapeutic agent includes a compound having activity in suppressing the expression and/or the function of frizzled-2. The compound having activity in suppressing the expression and/or the function of frizzled-2 is siRNA to frizzled-2. Further, the compound having activity in suppressing the expression and/or the function of frizzled-2 is shRNA to frizzled-2. When Hep3B and MIA-Paca2 are selected as a liver cancer and a pancreas cancer cell lines, and the expression level of Cyclin D1 is analyzed, in both the cell lines, the expression level of Cyclin D1 reduces.