GENETIC POLYMORPHISM ASSOCIATED WITH CORONARY HEART DISEASE, METHOD OF DETECTION AND USE THEREOF

摘要

PROBLEM TO BE SOLVED: To provide genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof.SOLUTION: The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease and in particular stenosis and MI and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection. The present invention relates to the identification of new SNPs, unique combinations of such SNPs, and haplotypes of SNPs that are associated with CHD, and in particular stenosis and MI.