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Novel immunogenic lipopeptides comprising a T helper epitope and a cytotoxic T lymphocyte (CTL) epitope
Novel immunogenic lipopeptides comprising a T helper epitope and a cytotoxic T lymphocyte (CTL) epitope
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机译:新型免疫原性脂肽,包含T辅助表位和细胞毒性T淋巴细胞(CTL)表位
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摘要
The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and CTL epitopes, and methods for their production and use in the generation of primary and secondary immune responses, and for the vaccination of animal subjects against particular CTL epitopes. More particularly, the present invention provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog, preferably to the terminal side-chain group of an internal diamino acid residue. Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the CTL epitope.
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