How to predict the effects of heart failure apheresis therapy

摘要

The present invention provides methods for predicting an effectiveness of apheresis therapy on patients with dilated cardiomyopathy, which include adding, for example, sera or such collected from patients to 18-day-old chicken fertile eggs and measuring the left ventricular ejection fraction of the eggs. High reproducibility was achieved by using urethane as an anesthetic agent for the chicken fertile eggs, maintaining the eggs in incubation sand at 40° C. during measurement, and using an ultrasonic probe with a frequency of 10 MHz or more. When the left ventricular ejection fraction is less than 90%, apheresis therapy is likely to be effective. Indeed, it has been clinically demonstrated that the apheresis therapy is successful when the left ventricular ejection fraction is improved to 90% or more by the therapy.