Building a bridge reagent for interaction analysis between molecules

摘要

This invention has stated the use of the building a bridge reagent of the specification which contains the 1 hydroxy benzo triazole or the 1 hydroxy 7 azabenzotoriazoru basis, as a reactivity basis for the building a bridge reaction of the super molecular target - ligand - mixture. Can the building a bridge product which it occurs, analyze directly mass spectrometry, making use of gel or fluorescent based method, x-ray crystallography method, NMR method or other analysis. This method of using High-Mass MALDI mass spectrometry, quality decision and the creation medicine of the antibody, and seems like the protein mixture analysis which includes the application of the automatic or high throughput, various biological applications are offered.