How to identify the methylation of VEGFR1 adjustment factor due to SMYD3

摘要

Modifiers methyltransferase activity and method for determining the methyltransferase activity of the polypeptide, in particular, the present invention relates to methods of screening for modifier of methylation of VEGFR1 that by SMYD3. Furthermore, the present invention provides methods and pharmaceutical compositions for treating and preventing colorectal cancer using modifiers identified in this way, hepatocellular carcinoma, breast and bladder cancer and / or.